Saturday, March 27, 2010


I was prescribed Endome.trin, a vaginal suppository instead of PIO (progesterone in oil) shots this cycle.  This is used to prepare the uterine lining to nourish and support a fertilized egg after egg retrieval during an IVF cycle.
(image from

I am grateful for Endome.trin instead of PIO.  But I was directed by the doctor to continue to use this even though my transfer was cancelled.  According the nurse, they want my body to continue mimicking the luteal phase.  I am to continue for a total of 10 days then stop.  I should expect AF a 3 to 5 days after that.

Endome.trin can be messy, but nothing a panty liner cannot fix.  But it can be a real pain, literally.  I've had daily uterine cramps, sometimes mild, but other times intense.  I've also felt cramps like I'm severely constipated, but I'm not.  It feels the worst in the mornings when I first wake up, and I feel the intense need to pee first thing in the morning.  I've already been woken up in the middle of the night with these cramps more than once.  These are normal side effects of Endo.metrin.  During my last IVF cycle, I used gel instead, which is had some side effects, but I don't remember it being like this.

I can handle all these side effects.  The physical discomfort is no big deal.

The kicker about this though is that thanks to these side effects, I am reminded daily and constantly that my transfer was cancelled.  That I should be PUPO (pregnant until proven otherwise), that I should be in my 2WW.  Instead, I am waiting to hear if I can see my RE before May 5th.  And yet, I have to experience these side effects.

Thankfully, I only have a few days left to take it.  My last dose will be on Tuesday..... please come soon.

On a positive note, I am feeling better.  I have not cried in bed the last couple of nights now.


  1. Hang in there and know that I send you love and well wishes. I know your heart is hurting, but know that I am hopeful for you....I too find myself in a precarious place, as I have to wait until June 3rd to see an RE and see what comes next. I'm afraid and feel as if I'm already walking on thin ice.

    However, we have to stay the course and persevere in search of our dream. As someone your age, I understand what you are going through and once again I'm sorry.

    Many Hugs and Much Love

  2. Ugh...the suppositories are the worst when you ARE in the 2ww...I'm so sorry that you are dealing with this annoying non-2ww! I hope you get in to see the RE soon and the next cycle is a go!

  3. I've never had to use the PIO, just the Not fun at all! Messy! Yucky!

    I hope Tuesday comes fast for you.

  4. Oh, I just hate all of this for you. With Matthew's cycle last year, I used the Endometrin and didn't like the mess but was SO glad it was only the vagi-pops (as I affectionately called them) and not the PIO because I was SO scared of the PIO!
    For this last FET, they wanted me to do PIO and I was nervous--but they weren't anywhere near as bad as I expected. Thankfully.

    But you're right--regardless, it stinks. It stinks that we have to go through this and it stinks that we go through it and still end up with empty arms.

    I am so, so sorry for you having to do this even though your transfer was cancelled. Talk about rubbing salt in the wound. As I say each day, I pray that you can get in to your RE sooner than May 5 so that if there's anything differently they'd do, you could be on it instead of just waiting and being tortured. I wish it could be different for you, and in the meantime, I will keep praying.

  5. I am so sorry you have to endure this as well.I wonder why your doctor wants you to keep taking them. You are such a strong person, I read it in your posts and I know the next cycle will be the one that works out for you!!! I so wanted this to be your miracle and my heart breaks for you that it wasn't... but i am confident you will be a mom sooner than you think and what a GREAT mom you will make!! Sending you a massive hug!!! You are in my prayers.

  6. I'm so sorry that you aren't pupo and you still have to go through the motions and the daily reminders that you don't have a chance this month.

    And I HATE endo.metrin. It's so goopy...and just gross. I feel crazy bloated on it too.

    Ihope all of this effort is worth it for the next cycle.

  7. I just found your blog and couldnt leave without sending you my love. It is so heartbreaking when things don't go as you had expected. I think the hardest part is that you can sometimes mentally prepare yourself for a bfn at the end of a two week wait but to have the rug pulled out from under you so early in the piece is really hard. I have had 3 failed IVFs and I always struggle with low fertilisation rates so know that feeling of having all your hopes on one or two embryos and then to have them dashed just as quickley. I hope as the days go on you start feeling stronger, you've endured a lot and none of it is fair. Thinking of you.